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CBD Tolerance: Can Patients Build Tolerance to CBD?

We all know that cannabis can cause addiction.

Like all psychoactive substances, it has a strong impact on our brain, and there are certain issues that go with that.

A big part of the problem is how our body interacts with THC. After a while, patients will start developing tolerance making it harder and harder to get high.

But what about CBD tolerance? How does this substance react?

A lot of people are worried that prolonged cannabidiol use will increase your tolerance to the CBD substance.

As a result, the whole treatment would become less effective, and you would need additional dosage to achieve the same effect.

This can also be hazardous as we don’t know what would happen if medical patients started implementing steadily increasing quantities of CBD.

The companies present cannabidiol as a wondrous drug, often neglecting their drawbacks.

Truth be told, the substance can provide relief for pain, muscle spasms, various mental issues, insomnia, arthritis, etc. Unfortunately, the question of CBD tolerance is often pushed aside. 

While cannabidiol is quite safe (especially when compared to THC), it does change chemicals in your body. It has a strong sedative effect making it harder to drive or use heavy machinery afterward.

In fact, we recommend that you use it in the evening, before going to bed. Then again, it all depends on what medical condition patients want to treat.

Explaining cannabidiol tolerance

CBD tolerance is a very simple process to explain. It is common for drugs and other addictive substances.

When medical patients use one of these substances for a longer period of time, it becomes harder and harder to get high or drunk.

This is why people who developed a strong addiction are forced to take increased quantities in order to achieve the same results.

Tolerance works on several levels. It has an impact on our cells that slowly become "numb" to the stimuli. After a while, the cells in our body will not create the same response as they did initially.

Another example of CBD tolerance can be seen through our metabolism's inability to process the same quantities of the substance after a while.

Lastly, after a while, we will get used to the intoxication, and we will not perceive it in the same way as before. 

How does THC work?

A lot of CBD products have THC as well.

Usually, the allowed THC content is limited to 0.3% and lower, but that doesn’t mean that the substance cannot have an impact on your body.

THC is the main psychedelic substance present in marijuana. It is the reason why one may feel "stoned" when they ingest it.

If medical patients use it for a longer period of time, they will slowly start building a tolerance. So much so, that some users stop getting high after a while and need increased quantities to feel a kick.

There are lots of things to be considered when it comes to THC tolerance. Every individual will develop a different tolerance depending on their physiology.

We should also consider differences based on weight, age, and sex. The tolerance occurs on a cellular level. The substance binds to CB1 receptors that can be found in the human brain.

While we shouldn’t neglect the impact of THC (especially if you’re using full-spectrum CBD products), our focus should still be on cannabidiol.

CBD is a completely different substance compared to THC. It promotes relaxation, making it ideal for ailments such as insomnia, stress, and anxiety.

It also has different tolerance features, which we will talk about in the upcoming chapter. Check it out!

CBD tolerance and the endocannabinoid system

CBD affects CB1 receptors in a completely different way compared to some other cannabinoids. In this particular case, cannabidiol works as an antagonist.

In other words, it doesn't have the same ability to bind to the receptor as some other cannabinoids. Furthermore, it weakens CB1's ability to interact with other cannabinoid substances.

This is precisely why CBD is often paired with THC and other cannabinoids: while THC binds aggressively, CBD allows the receptor to "cool off." In a way, they are negating each other, bringing about a perfect balance.

Another interesting feature of CBD is that it increases the number of endocannabinoids within a body. Oftentimes, the medical cannabis experts present CBD as an endocannabinoid-reuptake inhibitor.

Can medical patients become CBD tolerant? 

Now, to answer the main question: can you become CBD tolerant?

Based on all the studies we've performed so far, we can conclude that CBD doesn't cause CBD tolerance. Even better, it may produce an effect that is totally opposite to tolerance.

Instead of having to use larger and larger quantities of the substance to achieve the same effect, you will use smaller and smaller.

Another interesting thing is that, due to CBD's impact on CB1, the substance is able to modulate the behavior of THC within the body. It wouldn’t be surprising if medical cannabis users started adding CBD as a way to adjust their tolerance.

Of course, like all other things CBD related, we still need much more research to be fully certain of these claims. For now, it seems that the substance is pretty harmless in terms of CBD tolerance development.

If you add the fact that CBD doesn't cause many side effects, and that it is really beneficial, it becomes clear that the product has a great future. 

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